EXAMINE THIS REPORT ON LDN-27219 POTENTIAL THERAPEUTIC APPLICATIONS

Just one specially exciting compound is LDN-27219. Though most tTG inhibitors are meant to bind on the protein crosslinking Lively web-site, LDN-27219 alternatively binds for the nucleotide binding pocket of the enzyme though it can be in its closed-condition conformation, and stabilizes that conformation to prevent crosslinking activity.78 Schneid